Jae-Seong Yang

Department
Molecular Genetics
Job Title
Group Leader
INSTRUCTION LANGUAGES
English, Korean

PERSONAL BIO

He obtained his Ph.D. as a computational biologist at POSTECH, South Korea. During my Ph.D. training, he actively participated in various research projects that required data interpretations, machine learning, and communication with experimental biologists. Next, he moved to Barcelona in Spain where he worked as a postdoctoral researcher at Prof. Luis Serranos Lab (CRG). Initially, his position was supported by the European collaborative research project (PRIMES), and then he obtained a Juan de la Cierva fellowship. During this period, he developed a novel high-throughput method to investigate hundreds of thousands of synthetic promoters, revealing key sequences that determine transcription efficiency in Mycoplasma pneumoniae (Nature Comm. 2017). Further, he developed another method to identify protein-protein and RNA-protein interactions at an ORFeome-wide scale (Nature Comm. 2018, Methods 2019). Later, he moved to POSTECH in Korea, working as a Research Assistant Professor with my own Research Fellow funding from the National Research Foundation of Korea.

As a Junior Group leader at the Centre for Research in Agricultural Genomics (CRAG), since September 2019, he has started his independent research group on Computational and Synthetic Biology, with the initial goal of developing a bioengineering platform for photosynthetic cell factories, using two novel methods he developed during his post-doc period. He has been awarded the Plan Estatal grant (PID2020-117772GA-I00) from the Spanish Government MINECO to fund the main project of the lab and Ramón y Cajal (RYC2020-028880-I).

During this first stage and adaption to the CRAG, he already lead many fruitful collaborations as a principal investigator (inter)nationally and it has recently been published two papers as a co-corresponding author (Metab Eng. 2022 and Nat Commun. 2022) and a corresponding paper (Journal of Experimental Botany 2023).

Among the most relevant achievements in his career he highlight the following:

(1) Studies of model bacterial translation regulation and development of 5 UTR design tools (2 papers)

(2) Studies of non-model bacterial transcription and translation regulation (3 papers)

(3) Studies of protein-protein and RNA-protein interactions (4 papers)

(4) protein-protein interactions with structural and evolutionary analysis (6 papers)

(5) Studies of Single/Multiple localized proteins and sub-organellar localization (4 papers)

(6) Structural and evolutionary analysis of enzyme and enzyme engineering (4 papers)

(7) Developing statistical tools for the analysis of aging data (6 papers)

(8) First author of 7 free/open-source software (OASIS, UTRDesigner, UTRLibrary, SAPIN, TAPAS, ELMSeq, recYnH)

(9) Awarded by several and prestigious competitive fellowships from national calls (Juan de la Cierva-incorporation, Research Fellow, a junior group leader from Severo Ochoa, Ramon y Cajal)

(10) Got R3 certification (2023/11/08) and passed the CSIC oposiciones exam (2023/11/15)

WORK EXPERIENCE AND AWARDS

  • Group Leader, CRAG, Spain (2019-present)
  • Research Assistant Professor, POSTECH, Korea (2018-2019)
  • Post-doc., CRG, Spain (2012-2018)

EDUCATIONAL BACKGROUND

  • Ph.D., in Computational Biology, POSTECH, Korea
  • Master in Computational Biology, POSTECH, Korea
  • Bachelor in Life Science and Computer Engineering (double major), POSTECH, Korea

VacancIES