During L. María Lois's career, she has performed pioneer studies that have been the foundation of new research lines of two novel biological processes: the elucidation of a novel metabolic pathway for isoprenoid biosynthesis and the role of SUMO conjugation as a novel posttranslational modification. Linked to my activity at CRAG, she has been awarded an ERC-starting grant and an ERC-PoC grant.
In 2004, she joined the University of Barcelona (UB) as a young group leader. In 2008, she was appointed to the Spanish Research Council CSIC as Assistant Professor, for establishing my research group. Her interest in pursuing the study of SUMOylation in plants was related to being an unexplored essential process and on its potential for biotechnological applications.
In addition, she has developed a translational research activity aiming to develop SUMO conjugation inhibitors, which have applications in biomedicine, but also in agriculture. Related to this, she received training in business development by the University of Berkeley (2015) and by “La Caixa” Foundation (2017) in the context of the Caixa Impulse Program, for bringing the results to the next step into their commercialization process.
She has obtained local (SGR2008, 2014 and 2017, Llavor 2014, Beatriu de Pinós 2013, Producte 2018), national (BIO2004, 2008 and 2017, FPU2012, CaixaImpulse 2017) and European (ERC-StG2007, ERCPoC2014, EMBO short-term 2014, COST STM2015 and 2021, MSCA-Global 2022) funding grants. In addition to peer review scientific publications, She has edited two books of protocols on Plant Proteostasis (2016 and 2023, Springer). In 2016, she led the organization of a BDebate workshop on Plant Proteostasis and she contributed to the organization of a New Phytologist workshop in 2018 (Durham, UK). In 2023, she coorganized the first EMBO workshop on SUMO, which has gathered experts from biomedicine and plant sciences.
Plants are a primary source of nutrients, chemicals, and materials for humans. Our program aims to generate fundamental knowledge on plant physiology and metabolism and to use this knowledge to improve crops through plant synthetic and metabolic engineering approaches. We are interested in deciphering the control of primary and secondary metabolism for the production of high-quality bioproducts and the enhancement of plant performance and yield. Furthermore, by using a synthetic biology framework, we aim to contribute to the advancement of basic plant research and provide novel biotechnological tools.
In particular, our Program addresses the study of the regulation of isoprenoid and lignin biosynthetic pathways, the organization of the cell endomembrane system, the fixation of carbon through photosynthesis, and the development of microalgae as a bioengineering and synthetic biology platform. These pathways and processes impact yield, fruit and seed quality, nutritional content, digestibility, bioenergetic value, and tolerance to biotic and abiotic stress. Our work aims to develop technologies to reprogram plant cells, including the design of genetic circuits for fine tuning gene expression, the design of novel metabolic pathways, and the use of plant cells as biofactories to express molecules of therapeutic interest.
The experimental approaches emerge from the biochemistry, genetics, molecular, and cell biology fields, and include advanced plant/microalgae system methodologies with transcriptomic, proteomic and metabolomic analyses. A substantial part of the research activities is performed in well-established models (Marchantia or Arabidopsis), crop plants (tomato, rice, and maize), and microalgae (Chlamydomonas and Chlorella).
The intern shall be given the opportunity to join the following research groups:-
From June 10 to September 1, 2024 (adjustable at the discretion of the organisation)