
Laura Botigué leads the group of Genomics for Ancient Crops and Domestication at the Centre for Research in Agricultural Genomics (Barcelona, Spain). She studies genome evolution in crops to understand the changes that wild species underwent as they adapted to agriculture. To do this, she applies population genetics theory and bioinformatics to analyse the genetic variability of crop wild relatives, ancient DNA, traditional landraces, and modern varieties. Her current work focuses mainly on crops that originated in the Fertile Crescent, particularly wheat and flax.
Laura Botigué obtained her PhD in 2012 from the Universitat Pompeu Fabra, where she studied the history of human populations in North Africa under the supervision of Prof. David Comas. Her work characterised the genetic architecture of North African populations, their origins, and their migrations with neighbouring regions, and was published in Botigué, Henn et al. (2013) in PNAS and Henn, Botigué et al. (2012) in PLoS Genetics. She then moved to Stony Brook University with Prof. Brenna Henn under a Postdoctoral Fellowship from the Catalan Government to continue her research on human populations, and additionally began a research line on dog ancient DNA with Prof. Krishna Veeramah (Botigué et al. 2017, Nature Communications).
Towards the end of her postdoctoral work, she decided to continue her research on ancient DNA with a focus on plants and domestication. In 2017, she began a collaboration with researchers from University College London on ancient wheat (Scott, Botigué et al. 2019, Nature Plants) and joined the Royal Botanic Gardens, Kew (UK) as a Bioinformatician (Zuntini et al. 2024, Nature). One year later, she joined the Centre for Research in Agricultural Genomics as a Junior Group Leader, and in 2020 obtained the prestigious Ramón y Cajal Fellowship to consolidate her research group on ancient crops and domestication. She was awarded tenure in 2024 as a CSIC Scientist.
Research within the Plant and Animal Genomics Programme focuses on understanding the organization, evolution, and variability of crop and domestic animal genomes, uncovering their domestication processes, and elucidating the genetic basis of traits relevant to crop and livestock improvement. The Programme is structured into six research groups that routinely employ a wide range of genetic, genomic, paleogenomic, bioinformatic, statistical, population genetics, and phenotypic approaches across crops such as melon, peach, apple, strawberry, and wheat, as well as livestock species including pig and goat.
We develop bioinformatics methodologies and software tools for genome data analysis, and we apply gene-editing technologies for the functional validation of candidate genes associated with traits of interest. The main objective of the Plant and Animal Genomics Programme is to translate genomic information into phenotypes; accordingly, some of our research activities are carried out in collaboration with private companies and public institutions through commercial breeding programmes.
The project forms part of the Catalan Biogenome Project, an initiative within the Earth Biogenome Project (EBP). The EBP aims to generate a reference-quality genome assembly for every eukaryotic species on Earth. As climate change and the over-exploitation of natural resources continue to impact biodiversity and disrupt ecosystems worldwide, high-quality genome assemblies have become essential for informing conservation policies and supporting nature-based solutions.
Dr Botigué leads a consortium of more than 11 researchers dedicated to generating genome assemblies of plant species. Using long-read sequencing, Hi-C, and transcriptome data, the project’s main goals are to assemble complete genomes, annotate repetitive and functional elements, and publish high-quality reference genomes.
This internship offers an excellent opportunity to gain experience in genome assembly and to work with a broad range of bioinformatic tools. Students will also have the chance to engage with the wider EBP and the European Reference Genome Atlas communities by attending relevant meetings. Because the plant species involved vary widely in mating systems, repetitive DNA content, and genome size, there is no single universal strategy; students will learn to evaluate and troubleshoot results at each stage of the workflow. Among the species available is Crepis triasii, an endemic plant from the Balearic Islands whose populations have shifted with past sea-level changes, providing a useful model for studying natural adaptation to climate change in endemic species.
For some species, Hi-C DNA extraction is still required, so opportunities to gain wet-lab experience are also available. This part of the project is carried out in collaboration with researchers at CREAF. Completed genomes will be published in manuscripts and made available according to EBP guidelines.
From June 15 to August 31, 2026 (adjustable at the discretion of the organisation)